Diepoxymontin, a Novel Acetogenin from Annona montana

Abstract

Tandem mass spectrometry has been used to elucidate the structure of diepoxide a, Punsaturated -y -lactonic acetogenin, diepoxymontin, which is the first example of acetogenin having an adjacent epoxides in place of tetrahydrofuran moiety.In the previous papers, 2.3 we have reported the presence of some cytotoxic acetogenins from the leaves of Formosan Annona reticulata.As part of our continuing investigation on the acetogenins of Formosan Annonaceous plants, we have isolated several acetogenins from the chloroform extract of fruits of A. montana.4One of these, diepoxymontin(l), presents a novel structure in which the tetrahydrofuran systems are replaced by adjacent epoxy groups.We report herein the structural elucidation of 1. 35