Combined inhibition of DNA methylation and histone acetylation enhances gene re-expression and drug sensitivity in vivo

<i>MGMT</i> Gene Silencing and Benefit from Temozolomide in Glioblastoma

Monika E. Hegi, Annie‐Claire Diserens, Thierry Gorlia et al. · New England Journal of Medicine · 2005 · 7.1K citations · Full text

Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer

Elizabeth E. Cameron, Kurtis E. Bachman, Sanna Myöhänen et al. · Nature Genetics · 1999 · 1.9K citations

Histone Modifications, Chromatin, Radiation Oncology +12

A genomic screen for genes upregulated by demethylation and histone deacetylase inhibition in human colorectal cancer

Hiromu Suzuki, Edward Gabrielson, Wei Chen et al. · Nature Genetics · 2002 · 854 citations · Full text

Histone Modifications, Chromatin, Genomic Screen +13

Reversal of drug resistance in human tumor xenografts by 2'-deoxy-5-azacytidine-induced demethylation of the hMLH1 gene promoter.

Jane A. Plumb, Gordon Strathdee, Julieann Sludden et al. · PubMed · 2000 · 488 citations

Gene Promoter Hypermethylation, High Frequency, Cancer Biology +17

A role for methylation of the hMLH1 promoter in loss of hMLH1 expression and drug resistance in ovarian cancer

Gordon Strathdee, Melanie Mackean, Maureen Illand et al. · Oncogene · 1999 · 351 citations · Full text

Medicine, Gynecology, Cancer Genomics +9