Ex Situ Inhibition of Hepatic Uptake and Efflux Significantly Changes Metabolism: Hepatic Enzyme-Transporter Interplay

Inhibition of P-Glycoprotein–Mediated Drug Transport

Martin F. Fromm, Richard B. Kim, C. Michael Stein et al. · Circulation · 1999 · 400 citations

Medicine, Pharmacokinetics, Pharmacology +16

Isolation of a multispecific organic anion and cardiac glycoside transporter from rat brain

Birgitta Noé, Bruno Hagenbuch, Bruno Stieger et al. · Proceedings of the National Academy of Sciences · 1997 · 396 citations

Life Sciences, Biochemistry, Pharmacology +11

Transport of digoxin by human P-glycoprotein expressed in a porcine kidney epithelial cell line (LLC-PK1).

Yusuke Tanigawara, Noboru Okamura, Midori Hirai et al. · Journal of Pharmacology and Experimental Therapeutics · 1992 · 336 citations

Medicine, Cell Biology, Pharmacology +17

Unmasking the Dynamic Interplay between Intestinal P-Glycoprotein and CYP3A4

Carolyn L. Cummins, Wolfgang Jacobsen, Leslie Z. Benet · Journal of Pharmacology and Experimental Therapeutics · 2002 · 287 citations

Pharmacy, Pharmacokinetics, Pharmacology +17

Interaction Between Quinidine and Digoxin

Edward B. Leahey · JAMA · 1978 · 224 citations

Medicine, Pharmacology, Pharmacotherapy +11