Accurate Dialysis Dose Evaluation and Extrapolation Algorithms During Online Optical Dialysis Monitoring

Abstract

The aim of this study was to propose an improved method for accurate dialysis dose evaluation and extrapolation by means of Kt/ V from online UV-absorbance measurements for real time and continuous treatment monitoring. The study included a total of 24 treatments from ten uremic patients, seven of whom were male and three females. All patients were on chronic thrice-weekly hemodialysis therapy. The study included both stable and unstable treatments. A known signal processing algorithm, Levenberg-Marquardt, and the newly developed SMART were utilized for the removal of disturbances not relevant for dialysis dose evaluation. Finally, the results were compared with the Kt/ V values based on the blood samples. The new data processing algorithm, SMART, removes disturbances, helps estimate the online Kt/ V with significant precision increase and without any time delay, and more effectively predicts the end Kt/ V for the treatment than the known algorithms.