Clinical Trials of p-(Di-2-chloroethylamine)-phenylbutyric Acid (CB 1348) in Malignant Lymphoma

Abstract

Everett, Roberts, and Ross (1953) synthesized a series of water-soluble aromatic nitrogen mustards, one of which, p-(di-2-chloroethylamino)-phenylbutyric acid (CB 1348), was found to be a powerful inhibitor of the transplanted Walker rat tumour 256 (Haddow, 1952) and was sub- mitted for clinical trial.