Chiral 1-alkoxyaziridines: resolution, nitrogen inversion, stucture and diastereomeric transformations

Abstract

The resolution of enantiomers by chiral chromatography and the determination of nitrogen inversion activation parameters by dynamic chromatography have been carried out for aziridines 1–3; the structures of aziridines 4–7 have been studied; the complete diastereomeric transformation of (S,R)-(+)-8a into (R,R)-(–)-8b has been performed, and the conglomerate of high-melting diastereomer (±)-9 has been found.