Synthesis of 3′-azido-2′,3′-dideoxy-5-fluorouridine phosphoramidates and evaluation of their anticancer activity

New Colorimetric Cytotoxicity Assay for Anticancer-Drug Screening

Philip Skehan, Ritsa Storeng, Dominic A. Scudiero et al. · JNCI Journal of the National Cancer Institute · 1990 · 9.8K citations

Medicine, Oncology, Pharmacology +10

3'-Azido-3'-deoxythymidine (BW A509U): an antiviral agent that inhibits the infectivity and cytopathic effect of human T-lymphotropic virus type III/lymphadenopathy-associated virus in vitro.

Hiroaki Mitsuya, Kent J. Weinhold, P A Furman et al. · Proceedings of the National Academy of Sciences · 1985 · 1.9K citations · Full text

Life Sciences, Infectious Diseases, Molecular Biology +17

Atom/Fragment Contribution Method for Estimating Octanol–Water Partition Coefficients

William M. Meylan, Philip H. Howard · Journal of Pharmaceutical Sciences · 1995 · 866 citations

Natural Sciences, Chemistry, Physical Chemistry +5

Prodrugs of Phosphates and Phosphonates

Scott J. Hecker, Mark D. Erion · Journal of Medicinal Chemistry · 2008 · 412 citations

Pharmacy, Medicinal Chemistry, Pharmacology +8

Structure−Activity Relationship for Thiohydantoin Androgen Receptor Antagonists for Castration-Resistant Prostate Cancer (CRPC)

Michael E. Jung, Samedy Ouk, Dongwon Yoo et al. · Journal of Medicinal Chemistry · 2010 · 264 citations

Pharmacy, Medicinal Chemistry, Pharmacology +15