Concepedia

Structures of human microsomal cytochrome P450 2A6 complexed with coumarin and methoxsalen

Jason K. Yano, Mei‐Hui Hsu, Keith J. Griffin, C.D. Stout, Eric F. Johnson

Nature Structural & Molecular Biology · 2005 · 301 citations · 9 references

DOI

Concepts

References

9

Detection, delineation, measurement and display of cavities in macromolecular structures

Gerard J. Kleywegt, Thomas A. Jones · Acta Crystallographica Section D Biological Crystallography · 1994 · 971 citations

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A Proton-Shuttle Mechanism Mediated by the Porphyrin in Benzene Hydroxylation by Cytochrome P450 Enzymes

Sam P. de Visser, Sason Shaik · Journal of the American Chemical Society · 2003 · 368 citations

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Inhibition of cytochrome P450 2A6 increases nicotine's oral bioavailability and decreases smoking

Edward M. Sellers · Clinical Pharmacology & Therapeutics · 2000 · 180 citations · Full text

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Mechanism-Based Inactivation of P450 2A6 by Furanocoumarins

Luke L. Koenigs, William Trager · Biochemistry · 1998 · 108 citations

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Evidence for cytochrome P450 2A6 and 3A4 as major catalysts for N'- nitrosonornicotine alpha-hydroxylation by human liver microsomes

Christopher Patten · Carcinogenesis · 1997 · 101 citations · Full text

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