Autoimmune Polyendocrine Syndrome Type 1 in North-Western France: <i>AIRE</i> Gene Mutation Specificities and Severe Forms Needing Immunosuppressive Therapies

Abstract

APS1 appears to be rare in north-western France. We identified 4 cases with a severe form needing immunosuppressive therapy. The AIRE gene mutations are more like those found in north-western Europe than those found in Finland.