Publication | Closed Access
Analysis of the unbinding force between telomestatin derivatives and human telomeric G-quadruplex by atomic force microscopy
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Citations
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References
2011
Year
Atomic Force MicroscopyDna AnalysisMolecular BiologyUnbinding ForceCytoskeletonTelomestatin DerivativesDna NanotechnologyBiomechanicsMatrix BiologyDna ComputingBiophysicsMechanobiologyMacromolecular MachineDna ReplicationCell BiomechanicsStructural BiologyChromatinDimer BoundBinding ModesNatural SciencesExperimental BiophysicsMedicineExtracellular Matrix
The force analysis between a macrocyclic hexazole (6OTD) monomer/dimer and telomeric DNA using atomic force microscopy revealed the difference in their binding modes. The 6OTD dimer bound to the G-quadruplex more strongly than the monomer by sandwiching the G-quadruplex.
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