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SERUM PLACENTAL LACTOGEN (HPL) AS INDEX OF PLACENTAL FUNCTION
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1971
Year
FertilityReproductive HealthGynecologySerum Placental LactogenEmbryologyHigh-risk PregnancyReproductive EndocrinologyMaternal ImmunizationLactationPublic HealthPlacental ImmunologyPlacental DevelopmentInfertilityHpl LevelsHpl PresentMaternal HealthPlacental DiseaseMaternal-fetal MedicineSerum HplEndocrinologyPlacental FunctionPregnancyMedicine
ABSTRACT A rapid and reproducible radioimmunoassay for serum placental lactogen (HPL) allowed quantitation of the endocrine function of the placenta and of its follow up during gestation. During the course of pregnancy subjects were followed up in order to determine the normal range of HPL levels during pregnancy. Low and decreasing levels of serum HPL were noted in pregnancies with placental insufficiency. The large quantities of HPL present, its autonomous production by the placenta and its short half-life all combine to make its measurement of practical value in the management of high-risk pregnancies.