Red Cells Genetically Deficient in Carbonic Anhydrase II Have Elevated Levels of a Carbonic Anhydrase Indistinguishable from Muscle CA III^a

Abstract

Adult human red cells contain appreciable levels of two carbonic anhydrase (CA) isozymes, CA I (I 1.6 ?2.3 mg/g Hb) and CA I1 (1.8 ?0.3 mg/g Hb), as determined by radioimmunoassay (RIA).Recently, biochemical and immunological studies have demonstrated the presence of an additional red cell carbonic anhy-