Journal of the American Medical Association · 1929 · 208 citations · 9 references
MedicineSurgeryOrthopedicsReconstructive SurgeryWound HealingTissue RepairWound CareWound ClosureWound Healing PhysiologyWound Healing ResponseWound ManagementMechanical Loading In Wound HealingWound Biomechanics
An uncomplicated incised wound presents for analysis the simplest form of disease, for the injury is primarily mechanical and finished and the reparative process is not subject to the interference of further injury. It also falls well within the definition of a "self-limited disease" given by Jacob Bigelow,<sup>1</sup>as one "to which there is due a certain succession of processes, to be completed in a certain time; which time and processes may vary with the constitution and condition of the patient, and may tend to death, or to recovery, but are not known to be shortened, or greatly changed by medical treatment." Recovery in the case of a wound accomplishes two main purposes: the reconstruction of the gross continuity of the tissue involved and the restoration of its function. When the latter is that of weight bearing or of the transmission of physical stress, it is accomplished in the
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Alexis Carrel, Alice Hartmann · The Journal of Experimental Medicine · 1916 · 129 citations · Full text
Medicine, Dermatology, Surgery +13
P. Lecomte du Noüy · The Journal of Experimental Medicine · 1916 · 115 citations · Full text
Medicine, Dermatology, Surgery +13
T. Brailsford Robertson · BMJ · 1921 · 96 citations · Full text
Alexis Carrel · The Journal of Experimental Medicine · 1921 · 67 citations · Full text
Medicine, Dermatology, Surgery +13
Alexis Carrel · Journal of the American Medical Association · 1910 · 59 citations · Full text