Benzothiazoles as Rho-associated kinase (ROCK-II) inhibitors

Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension

Masayoshi Uehata, Toshimasa Ishizaki, Hiroyuki Satoh et al. · Nature · 1997 · 2.9K citations

Hypertension, Muscle Function, Signal Transduction +11

The p160 RhoA-Binding Kinase ROKα Is a Member of a Kinase Family and Is Involved in the Reorganization of the Cytoskeleton

Thomas Leung, Xiangqun Chen, Edward Manser et al. · Molecular and Cellular Biology · 1996 · 878 citations · Full text

Rok Alpha, Molecular Regulation, Molecular Biology +20

ROCK‐I and ROCK‐II, two isoforms of Rho‐associated coiled‐coil forming protein serine/threonine kinase in mice

Osamu Nakagawa, Kazuko Fujisawa, Toshimasa Ishizaki et al. · FEBS Letters · 1996 · 796 citations · Full text

Inhibition of Rho Kinase (ROCK) Leads to Increased Cerebral Blood Flow and Stroke Protection

Yoshiyuki Rikitake, Hyung-Hwan Kim, Zhihong Huang et al. · Stroke · 2005 · 369 citations · Full text

The Rho kinase inhibitor fasudil inhibits tumor progression in human and rat tumor models

Ying Han, Sandra L. Biroc, Weiwei Li et al. · Molecular Cancer Therapeutics · 2006 · 178 citations · Full text