Publication | Closed Access
Synthesis and study of the potential antiallergic activity of some pyrazole derivatives
32
Citations
0
References
1981
Year
Pharmaceutical ScienceOrganic ChemistryPharmacotherapyActive Bispyrazole 1ChemistryHeterocycle ChemistryPharmaceutical ChemistryMedicinal ChemistryPharmacological StudyMonopyrazole DerivativesCompound 1DerivativesAllergyPharmacological AgentPharmacologyHeterocyclicNatural SciencesPyrazole DerivativesPotential Antiallergic ActivityMedicineDerivative (Chemistry)Synthetic ChemistryDrug Discovery
The synthesis and study of the oral antiallergic activity of a series of monopyrazole derivatives (2-14) considered as analogues of active bispyrazole 1 are described. None of the compounds showed significant inhibition of the rat passive cutaneous anaphylaxis (PCA), with the exception of the already known 5-aminoindazole (2). The activity of this compound, is however, lower than that of compound 1.