Iodine-Deficiency-Induced Long Lasting Angiogenic Reaction in Thyroid Cancers Occurs Via a Vascular Endothelial Growth Factor–Hypoxia Inducible Factor-1–Dependent, But Not a Reactive Oxygen Species–Dependent, Pathway

Abstract

ID induces a long lasting angiogenic phenotype in thyroid cancer cells that occurs through VEGF induction via a pathway partially mediated by HIF-1, but not by ROS. These results suggest that, in contrast with normal cells, ID-induced angiogenesis in cancer cells occurs via alternative and likely less controlled routes, thereby leading to uncontrolled growth.