Substrate Rigidity Modulates Cell–Matrix Interactions and Protein Expression in Human Trabecular Meshwork Cells

Abstract

Extracellular matrix rigidity modulates cytoskeletal structures, protein expression patterns, signal transduction, and fibronectin deposition in HTM cells. ECM changes altering trabecular meshwork resiliency may therefore have significant effects on ocular outflow tract functions with implications in glaucoma.