Analysis of drug resistance and virulence‐factor genotype of Irish <i>Helicobacter pylori</i> strains: is there any relationship between resistance to metronidazole and <i>cagA</i> status?

Abstract

cagA(+) and vacAs1/m2 type was the dominant genotype in Irish H. pylori strains. Significant rates of metronidazole resistance were observed in cagA(-) group. cagA(-) strains tend to acquire metronidazole resistance in vitro. Absence of cagA might be a risk factor in development of metronidazole resistance.