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Dibasic inhibitors of human mast cell tryptase. Part 2: Structure–activity relationships and requirements for potent activity

Kenneth D. Rice, Vivian R. Wang, Anthony R. Gangloff, Elaine Y. Kuo, Jeffrey M. Dener, William S. Newcomb, Wendy B. Young, Daun Putnam, Lynne Cregar, Martin Wong,

Bioorganic & Medicinal Chemistry Letters · 2000 · 38 citations · 5 references

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References

5

Human β-tryptase is a ring-like tetramer with active sites facing a central pore

Pedro José Barbosa Pereira, Andreas Bergner, Sandra Macedo‐Ribeiro et al. · Nature · 1998 · 299 citations

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Tryptase Inhibitors Block Allergen-Induced Airway and Inflammatory Responses in Allergic Sheep

James M. Clark, W M Abraham, Cindy Fishman et al. · American Journal of Respiratory and Critical Care Medicine · 1995 · 208 citations

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Dibasic inhibitors of human mast cell tryptase. Part 1: Synthesis and optimization of a novel class of inhibitors

Kenneth D. Rice, Anthony R. Gangloff, Elaine Y. Kuo et al. · Bioorganic & Medicinal Chemistry Letters · 2000 · 29 citations · Full text

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Mast cell tryptase and asthma

M-Q. Zhang, H. Timmerman · Mediators of Inflammation · 1997 · 22 citations · Full text

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Emerging therapeutic targets in asthma: the rationale for mast cell tryptase inhibition

Kyle Elrod, Robert P. Numerof · Emerging Therapeutic Targets · 1999 · 13 citations

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