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Isolation of Isodrimenediol, a Possible Intermediate of Drimane Biosynthesis from <i>Polyporus arcularius</i>
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1996
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Drimane BiosynthesisSecondary MetaboliteChemical BiologyBiosynthesisBiochemical TaxonomyNatural Product BiosynthesisDrimane-type StructuresBiotransformationBiochemistryPossible IntermediateStrain Coproduces 7-Drimene-3,11,12-triolMetabolomicsNatural Product SynthesisPrimary MetaboliteRelated Drimane MetabolitesBiologyNatural SciencesMicrobiologyMedicine
Isodrimenediol, 5-(hydroxymethyl)-1,1,4a-trimethyl-6-methylenedecahydronaphthalen-2-ol (1), was isolated as a new microbial metabolite from Polyporus arcularius DSM 1021. The strain coproduces 7-drimene-3,11,12-triol (3) and two related drimane metabolites (4 and 5), suggesting that 1 is the first intermediate of biosynthesis of drimane-type structures.