A novel treatment approach for low grade lymphoproliferative disorders using PKC412 (CGP41251), an inhibitor of protein kinase C

Protein kinase C as a possible receptor protein of tumor-promoting phorbol esters.

Ushio Kikkawa, Yoshimi Takai, Yasushi Tanaka et al. · Journal of Biological Chemistry · 1983 · 886 citations · Full text

Chemoprevention Strategy, Cancer Biology, Tumor-promoting Phorbol Esters +19

Calcium-dependent protein kinase: widespread occurrence in various tissues and phyla of the animal kingdom and comparison of effects of phospholipid, calmodulin, and trifluoperazine.

J.F. Kuo, Rolf G. G. Andersson, Bradley C. Wise et al. · Proceedings of the National Academy of Sciences · 1980 · 572 citations · Full text

Signal Transduction, Molecular Physiology, Biochemistry +15

Lipid activation of protein kinase C.

Robert M. Bell, David J. Burns · Journal of Biological Chemistry · 1991 · 561 citations · Full text

Signal Transduction, Biochemistry, Natural Sciences +8

Programmed cell death and Bcl-2 protection in the absence of a nucleus.

Michael D. Jacobson, Julia F. Burne, Martin Raff · The EMBO Journal · 1994 · 552 citations · Full text

Signal Transduction, Cell Regulation, Apoptosis +9

A derivative of staurosporine (CGP 41 251) shows selectivity for protein kinase C inhibition and <i>In vitro</i> anti‐proliferative as well as <i>In vivo</i> anti‐tumor activity

Thomas Meyer, Urs Regenass, Doriano Fabbro et al. · International Journal of Cancer · 1989 · 408 citations