Apolipoprotein E modulates Alzheimer’s Aβ(1–42)-induced oxidative damage to synaptosomes in an allele-specific manner

Hydrogen peroxide mediates amyloid β protein toxicity

Christian Behl · Cell · 1994 · 2.1K citations

Life Sciences, Biochemistry, Neuroscience +14

A model for beta-amyloid aggregation and neurotoxicity based on free radical generation by the peptide: relevance to Alzheimer disease.

K. Hensley, John M. Carney, Mark P. Mattson et al. · Proceedings of the National Academy of Sciences · 1994 · 1.1K citations

Life Sciences, Biochemistry, Neuroscience +17

The Aβ Peptide of Alzheimer's Disease Directly Produces Hydrogen Peroxide through Metal Ion Reduction

Xudong Huang, Craig Atwood, Mariana A. Hartshorn et al. · Biochemistry · 1999 · 1.1K citations

Life Sciences, Biochemistry, Chemistry +17

Apolipoprotein E allele–specific antioxidant activity and effects on cytotoxicity by oxidative insults and β–amyloid peptides

Masaaki Miyata, Jonathan D. Smith · Nature Genetics · 1996 · 887 citations

Life Sciences, Biochemistry, Toxicology +17

A Role for 4‐Hydroxynonenal, an Aldehydic Product of Lipid Peroxidation, in Disruption of Ion Homeostasis and Neuronal Death Induced by Amyloid β‐Peptide

Robert J. Mark, Mark A. Lovell, William R. Markesbery et al. · Journal of Neurochemistry · 1997 · 778 citations

Life Sciences, Neurobiology, Neuroscience +17