Concepedia

Correlating Excipient Effects on Conformational and Storage Stability of an IgG1 Monoclonal Antibody with Local Dynamics as Measured by Hydrogen/Deuterium-Exchange Mass Spectrometry

Prakash Manikwar, Ranajoy Majumdar, John M. Hickey, Santosh V. Thakkar, Hardeep S. Samra, Hasige A. Sathish, Steven M. Bishop, C. Russell Middaugh, David D. Weis, David B. Volkin

Journal of Pharmaceutical Sciences · 2013 · 104 citations · 75 references

DOI

Concepts

References

75

Primary structure effects on peptide group hydrogen exchange

Yawen Bai, John Milne, Leland Mayne et al. · Proteins Structure Function and Bioinformatics · 1993 · 1.9K citations

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The stabilization of proteins by sucrose.

James Lee, Serge N. Timasheff · Journal of Biological Chemistry · 1981 · 1.1K citations · Full text

, , +17

Stabilization of protein structure by sugars

Tsutomu Arakawa, Serge N. Timasheff · Biochemistry · 1982 · 1.1K citations

, , +7

Crystal Structure of a Neutralizing Human IgG Against HIV-1: A Template for Vaccine Design

Erica Ollmann Saphire, Paul W.H.I. Parren, Ralph Pantophlet et al. · Science · 2001 · 932 citations

, , +17

The Thermal Stability of Immunoglobulin: Unfolding and Aggregation of a Multi-Domain Protein

Arnoldus W. P. Vermeer, Willem Norde · Biophysical Journal · 2000 · 666 citations · Full text

, , +14