British Journal of Haematology · 2002 · 19 citations · 12 references
MedicineHematologyInternal MedicineDiagnostic AssessmentHemostasisVascular SurgeryDeep Vein ThrombosisThromboembolic DiseaseThrombosisThrombotic DisordersVenous DiseaseVenous ThromboembolismDeep Vein Thrombosis AssessmentDiagnostic StrategyNegative Predictive Value AssessmentPositive Predictive ValueProximal Deep Vein ThrombosisThromboembolism Risk PredictionVenous Thromboembolism AssessmentVenous Thromboembolism Diagnosis
The negative predictive value (NPV) of d-dimer (DD) for the exclusion of venous thromboembolism is, overall, high and tends to increase as clinical pretest probability decreases. We have assessed the accuracy of a diagnostic protocol including clinical evaluation and DD in 134 outpatients presenting with a moderate pretest probability of proximal deep venous thrombosis (DVT). In these patients, a negative DD value safely excluded DVT (NPV 100%, 95% CI 85-100) In our experience, these results are equivalent to those found for low-pretest probability patients and therefore the same diagnostic strategy can be used for both risk groups.
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Non-invasive diagnosis of venous thromboembolism in outpatients
Arnaud Perrier, Sylvie Desmarais, Marie‐José Miron et al. · The Lancet · 1999 · 796 citations
Fedde van der Graaf, HW Van den Borne, M van der Kolk et al. · PubMed · 2000 · 192 citations
Exclusion of Deep Venous Thrombosis with D-Dimer Testing
Henk van den Borne, Marion van der Kolk, Piet de Wild et al. · Thrombosis and Haemostasis · 2000 · 151 citations