Response to a specific antioestrogen (ICI 182780) in tamoxifen-resistant breast cancer

A potent specific pure antiestrogen with clinical potential.

A. E. Wakeling, Michael Dukes, Jean Bowler · PubMed · 1991 · 1.1K citations

Medicine, Endocrinology, Pharmacology +8

Role of the two activating domains of the oestrogen receptor in the cell‐type and promoter‐context dependent agonistic activity of the anti‐oestrogen 4‐hydroxytamoxifen.

M. Berry, Daniel METZGER, Pierre Chambon · The EMBO Journal · 1990 · 772 citations · Full text

Life Sciences, Molecular Biology, Pharmacology +14

Inhibition of estrogen receptor-DNA binding by the "pure" antiestrogen ICI 164,384 appears to be mediated by impaired receptor dimerization.

Stephen E. Fawell, R White, Susan Hoare et al. · Proceedings of the National Academy of Sciences · 1990 · 402 citations

Medicine, Endocrinology, Pharmacology +17

Acquired Tamoxifen Resistance: Correlation With Reduced Breast Tumor Levels of Tamoxifen and Isomerization of Trans-4-Hydroxytamoxifen

C. Kent Osborne, Ester B. Coronado, D. Craig Allred et al. · JNCI Journal of the National Cancer Institute · 1991 · 235 citations

Medicine, Oncology, Pharmacology +16

Original article: Response after withdrawal of tamoxifen and progestogens in advanced breast cancer

Anthony Howell, David Dodwell, H. Anderson et al. · Annals of Oncology · 1992 · 173 citations · Full text

Medicine, Oncology, Pharmacology +14