Diet Therapy With Diacylglycerol Oil Delays the Progression of Renal Failure in Type 2 Diabetic Patients With Nephropathy

Abstract

Diet therapy for diabetic nephropathy is important in preventing the progression of renal failure by controlling hyperglycemia, hypertension, hyperlipidemia, and obesity (1,2). Edible oil containing mainly diacylglycerol (DAG) oil, compared with conventional triacylglycerol oil, has been reported to possess unique nutritional properties with respect to serum lipids and body fat metabolism (3–6). We previously reported that a 3-month intake of DAG oil significantly reduced fasting serum triglycerides in subjects of type 2 diabetes with hypertriglyceridemia (7). In the present study, we conducted a further clinical study for 6 months with an additional 3-year follow-up period to investigate the long-term effects of DAG oil in dietary therapy in subjects with type 2 diabetes with nephropathy. The subjects were 15 outpatients (aged 47–77 years) at the Itami City Hospital who were diagnosed with type 2 diabetes in stage IIIb (macroalbuminuric stage with renal dysfunction; n = 2) and stage IV (renal failure stage; n = 13) according to the classification of diabetic nephropathy (Ministry of Health and Welfare, Japan) (8) who were receiving nutritional counseling for 13 months on average. The duration of diabetes was 18.2 ± 7.8 (range 5–28) years. Subjects were fully …