Science · 1966 · 109 citations · 10 references
MedicineImmunologyMolecular BiologyNucleic Acid BiochemistryRadiation BiophysicsRadiobiologyCellular Radiation ResponseDna ChemistryDna DamageRadiation ImmunobiologyRadiation SensitivityUltraviolet Radiation BiologyBovine Serum AlbuminDna Adducts From Ultraviolet RadiationUltraviolet-induced Dna DamageUv-induced Dna Lesions
A rabbit immunized with complexes of methylated bovine serum albumin and ultraviolet-irradiated DNA from calf thymus produced antibodies directed toward the photoproducts in the DNA. Serologic activity appeared after irradiation of DNA at 270 mmicro and decreased upon irradiation at 235 mmicro. The antigenic determinants of the ultraviolet-treated DNA appear to be photoproducts associated primarily with thymine, as measured by direct dependence of serologic activity on the adenine-thymine content of the DNA, and by inhibition of the Serlolgic reaction by the irradiated di-,tri-,and tetra-(thymidine-5'-phosphate nucleotides.
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The ultraviolet photochemistry of thymidylyl-(3′→5′)-thymidine
H. E. Johns, Mark Pearson, J. Leblanc et al. · Journal of Molecular Biology · 1964 · 192 citations
Photochemistry of thymine dimers
H. E. Johns, Seymour A. Rapaport, M. Delbrück · Journal of Molecular Biology · 1962 · 129 citations