Effect of different chemically modified oligodeoxynucleotides on immune stimulation

CpG motifs in bacterial DNA trigger direct B-cell activation

Arthur Μ. Krieg, Ae‐Kyung Yi, Sara Matson et al. · Nature · 1995 · 3.5K citations

Natural Sciences, Virulence Factor, Cpg Motifs +4

Regulation of viral expression of human immunodeficiency virus in vitro by an antisense phosphorothioate oligodeoxynucleotide against rev (art/trs) in chronically infected cells.

Makoto Matsukura, Gerald Zon, Kazuo Shinozuka et al. · Proceedings of the National Academy of Sciences · 1989 · 263 citations · Full text

Viral Replication, Immunology, Molecular Biology +20

Comparison of Cellular Binding and Uptake of Antisense Phosphodiester, Phosphorothioate, and Mixed Phosphorothioate and Methylphosphonate Oligonucleotides

Qiuyan Zhao, Sara Matson, Charles Herrera et al. · Antisense Research and Development · 1993 · 232 citations

Proteinlipid Interaction, Immunocytochemical Technique, Cellular Binding +15

Induction of anti-double stranded DNA antibodies in normal mice by immunization with bacterial DNA.

Gary S. Gilkeson, J P Grudier, Dennis G. Karounos et al. · The Journal of Immunology · 1989 · 204 citations · Full text

Laboratory Immunology, Immunology, Dna Analysis +17

Systemic Administration of a Phosphorothioate Oligonucleotide with a Sequence Complementary to p53 for Acute Myelogenous Leukemia and Myelodysplastic Syndrome: Initial Results of a Phase I Trial

Eliel Bayever, Patrick L. Iversen, Michael Bishop et al. · Antisense Research and Development · 1993 · 149 citations

Hematological Malignancy, Synthetic Phosphorothioate Oligonucleotide, Medicine +14