The uptake mechanism of PEGylated DNA polyplexes by the liver influences gene expression

A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine.

Otmane Boussif, Frank Lezoualc’h, Maria Antonietta Zanta et al. · Proceedings of the National Academy of Sciences · 1995 · 6.2K citations · Full text

Engineering, In Vivo Gene Therapy, Several Polycations +20

PEGylated DNA/transferrin–PEI complexes: reduced interaction with blood components, extended circulation in blood and potential for systemic gene delivery

Manfred Ogris, Silvia Brunner, Susanne Schüller et al. · Gene Therapy · 1999 · 1.2K citations

Systemic Gene Delivery, Blood Components, Medicine +8

The Liver Sieve: Considerations Concerning the Structure and Function of Endothelial Fenestrae, the Sinusoidal Wall and the Space of Disse

E. Wisse, R. B. de Zanger, K. Charels et al. · Hepatology · 1985 · 710 citations · Full text

Hepatology, Sinusoidal Wall, Liver Sieve +13

The Class B Scavenger Receptors SR-BI and CD36 Are Receptors for Anionic Phospholipids

Attilio Rigotti, Susan Acton, Monty Krieger · Journal of Biological Chemistry · 1995 · 548 citations · Full text

The Fate of Plasmid DNA After Intravenous Injection in Mice: Involvement of Scavenger Receptors in Its Hepatic Uptake

Kenji Kawabata, Yoshinobu Takakura, Mitsuru Hashida · Pharmaceutical Research · 1995 · 452 citations