Direct Chiral High Performance Liquid Chromatography Separation of O,O-Diethyl-(p-methyl-benzene-sulfonamido)- Aryl (Alkyl)-Methylphosphonate

Abstract

Abstract The enantiomers of a series of twelve O,O-diethyl, (p-methyl-benzenesulfonamido), aryl(alkyl)-methylphosphonates have been separated by high performance liquid chromatography on a Pirkle model chiral stationary phase. Chromatographic data and a chiral recognition model are presented for the separation of these organic phosphorus enantiomers on the chiral phase. The influence of column temperature and flow rate of mobile phase has been described.