Publication | Closed Access
The Inhalation Toxicity of Pyrolysis Products of Polytetrafluoroethylene Heated Below 500 Degrees Centigrade
51
Citations
10
References
1968
Year
Inhalation ToxicityChemistryComparative ToxicologyToxicological MechanismChemical EngineeringRat MortalityFire RetardancyAnalytical PyrolysisToxicologyApplied PyrolysisPrincipal Toxic ComponentBiochemistryPolytetrafluoroethylene HeatedExperimental ToxicologyPharmacologyPer- And Polyfluoroalkyl SubstancesInhalation ToxicologyPyrolysis ProcessNatural SciencesPyrolysis ProductsChemical ContaminantsApproximate Lethal TemperatureEnvironmental ToxicologyToxicokineticsMedicine
Abstract Quantitative evidence has been obtained which indicates that the principal toxic component in the pyrolysate from PTFE (Teflon® 5)∗ at the first temperature at which rat mortality is observed (Approximate Lethal Temperature, ALT), is a particulate material which may have other toxicants adsorbed on it. The toxicity of this particulate varies, depending upon the conditions under which it is generated. At 30°C above the ALT, perfluoroisobutylene could be the principal toxic agent. The data correlate well with known chemical reactions as well as observations and hypotheses of other investigators.
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