Variable F-18 fluorodeoxyglucose Avidity of Metastatic Recurrent Adult Granulosa Cell Tumor

Abstract

The appearance of rare ovarian germ cell tumors such as adult granulosa cell tumor (GCT) on F-18 fluorodeoxyglucose positron emission tomography (FDG-PET) is reported in this article. We present a patient with recurrent GCT and histologically proven intra-abdominal metastases. Most lesions were above PET resolution (>1 cm). The local recurrence demonstrated moderate FDG uptake but metastases had variable (none to mild) FDG avidity. Ovarian GCTs are of relatively low metastatic potential and frequently present as metastases with solid and cystic components, which are plausible explanations for its variable FDG uptake. Clinicians should be aware of this phenomenon and the potential for false negatives on FDG-PET.