The Japanese Journal of Pharmacology · 1988 · 51 citations · 14 references
MedicineNeurosciencePharmacologyNeurochemistryNeuropharmacologyPsychopharmacologyGabaergic PharmacologyGabaergic SignalingNeurotransmitter ReceptorsReceptor PharmacologySerotonergic PharmacologySerotonergic Signaling5-Hydroxytryptamine Receptor PharmacologyBinding AssaysLigand-binding AssaysReceptor Binding AssaysSerotonin Receptor BindingSerotonin Receptor PharmacologySerotonin Receptor SubtypesSerotonin Receptors
The propensity of SM-3997 to displace 3H-ligands was tested in vitro in a number of receptor-binding assays. SM-3997 possessed a high affinity towards 5-HT1A receptors, low affinity towards dopamine (D2) and 5-HT2 receptors, and no affinity towards benzodiazepine (BZ), GABA, 5-HT1B and adrenergic receptors. Moreover, SM-3997 facilitated neither 3H-flunitrazepam binding nor 3H-muscimol binding. These results suggest that the action of SM-3997 may be mediated via central 5-HT1A receptors but not the BZ-GABA receptor complex.
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Antipsychotic drug doses and neuroleptic/dopamine receptors
Philip Seeman, T. Lee, M. Chau-Wong et al. · Nature · 1976 · 1.6K citations
Medicine, Pharmacology, Psychiatry +13
Mark D. Tricklebank, Christian Forler, John R. Fozard · European Journal of Pharmacology · 1984 · 677 citations
Medicine, Neuroscience, Pharmacology +16