Publication | Closed Access
The Application of Electrospray Mass Spectrometry for Structural Studies on a Tetrasaccharide Monopeptide from the Urine of a Patient with α-N-Acetylhexosaminidase Deficiency
15
Citations
1
References
1994
Year
GlycobiologyBiological Mass SpectrometryMolecular BiologyCarbohydrate-protein InteractionElectrospray Mass SpectrometryAnalytical InstrumentationPositive Ion DetectionBioanalysisAnalytical ChemistryNew MethodologyChromatographyGlycosylationα-N-acetylhexosaminidase DeficiencyTetrasaccharide MonopeptideBiochemistryPharmacologyIon MobilityNatural SciencesMass SpectrometryProtein Mass SpectrometryNative Mass SpectrometryMedicineMolecular FragmentationDrug Analysis
Abstract In this contribution the introduction of a new methodology to sequence the glycopeptides using electrospray mass spectrometry (ES-MS) as a direct and efficient approach combining structural data obtained by negative and by positive ion detection is proposed. The main characteristics of this procedure are: i) good sensitivity in the low and the high mass range ii) induction of fragmentation processes at higher orifice voltages iii) no necessity for derivatization.
| Year | Citations | |
|---|---|---|
Page 1
Page 1