The Pharmacodynamic Interaction of Propofol and Alfentanil during Lower Abdominal Surgery in Women

Abstract

We defined the pharmacodynamic interaction between propofol and alfentanil for suppression of responses to perioperative stimuli during lower abdominal surgery. We conclude that propofol reduces alfentanil requirements for all studied clinical end points. In addition, alfentanil decreases propofol concentrations at which patients regain consciousness.