Publication | Closed Access
Fluorocyanation of Enamines
52
Citations
43
References
2010
Year
HalogenationPsychoactive DrugMedicineN-f ReagentFluorous SynthesisCyanide NucleophileOrganic ChemistryChemistryBeta-fluoroiminium Cationic IntermediatePharmacologyDrug Analysis
A method for the fluorocyanation of enamines has been described. The reaction involves fluorination of the electron rich double bond with N-F reagent (Selectfluor or NFSI) accompanied by trapping of beta-fluoroiminium cationic intermediate with cyanide nucleophile.
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