Concepedia

Fluorocyanation of Enamines

Alexander D. Dilman, Pavel A. Belyakov, Dmitry E. Arkhipov, Аlexander А. Korlyukov, Vladimir A. Tartakovsky

The Journal of Organic Chemistry · 2010 · 52 citations · 43 references

DOI

Concepts

Abstract

A method for the fluorocyanation of enamines has been described. The reaction involves fluorination of the electron rich double bond with N-F reagent (Selectfluor or NFSI) accompanied by trapping of beta-fluoroiminium cationic intermediate with cyanide nucleophile.

References

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William K. Hagmann · Journal of Medicinal Chemistry · 2008 · 3.6K citations · Full text

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Kenneth L. Kirk · Organic Process Research & Development · 2008 · 1.1K citations

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Kenneth L. Kirk · Journal of Fluorine Chemistry · 2006 · 892 citations

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Palladium-Catalyzed Fluorination of Carbon−Hydrogen Bonds

Kami L. Hull, Waseem Q. Anani, Melanie S. Sanford · Journal of the American Chemical Society · 2006 · 612 citations

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Enantioselective Formation of Stereogenic Carbon–Fluorine Centers by a Simple Catalytic Method

Mauro Marigo, Doris Fielenbach, Alan Braunton et al. · Angewandte Chemie International Edition · 2005 · 465 citations · Full text

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