Oxidants and not alkylating agents induce rapid mtDNA loss and mitochondrial dysfunction

Premature ageing in mice expressing defective mitochondrial DNA polymerase

Aleksandra Trifunović, Anna Wredenberg, Maria Falkenberg et al. · Nature · 2004 · 2.7K citations

Life Sciences, Genetics, Molecular Biology +12

Mitochondrial DNA Mutations, Oxidative Stress, and Apoptosis in Mammalian Aging

Gregory C. Kujoth, Asimina Hiona, Thomas D. Pugh et al. · Science · 2005 · 2.2K citations

Life Sciences, Genetics, Molecular Biology +17

Gene regulation and DNA damage in the ageing human brain

Tao Lu, Ying Pan, Shyan‐Yuan Kao et al. · Nature · 2004 · 1.9K citations

Life Sciences, Genetics, Neuroscience +16

Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress

F. Michael Yakes, Bennett Van Houten · Proceedings of the National Academy of Sciences · 1997 · 1.8K citations

Life Sciences, Cell Biology, Molecular Biology +15

Oxidative DNA damage and senescence of human diploid fibroblast cells.

Qian Chen, Ann Fischer, Jeff D. Reagan et al. · Proceedings of the National Academy of Sciences · 1995 · 711 citations

Life Sciences, Biochemistry, Cell Biology +17