Human recombinant dimeric IL-6 binds to its receptor as detected by anti-IL-6 monoclonal antibodies

THE ATTRACTIONS OF PROTEINS FOR SMALL MOLECULES AND IONS

George Scatchard · Annals of the New York Academy of Sciences · 1949 · 19.9K citations

Natural Sciences, Biophysics, Chemistry +9

Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin

Toshio Hirano, Kiyoshi Yasukawa, Hisashi Harada et al. · Nature · 1986 · 2.2K citations

Life Sciences, Immunology, Molecular Biology +16

Autocrine generation and requirement of BSF-2/IL-6 for human multiple myelomas

Michio Kawano, Toshio Hirano, Tadashi Matsuda et al. · Nature · 1988 · 1.7K citations

Medicine, Immunology, Oncology +11

Interleukin‐6 is the major regulator of acute phase protein synthesis in adult human hepatocytes

José V. Castell, Marı́a José Gómez-Lechón, Martina David et al. · FEBS Letters · 1989 · 901 citations

Life Sciences, Biochemistry, Physiology +16

Interleukin‐6 in synovial fluid and serum of patients with rheumatoid arthritis and other inflammatory arthritides

Frédéric Houssiau, Jean‐Pierre Devogelaer, Jo Van Damme et al. · Arthritis & Rheumatism · 1988 · 854 citations

Medicine, Immunology, Internal Medicine +10