A Common Variant of the Endothelial Nitric Oxide Synthase (Glu²⁹⁸→Asp) Is a Major Risk Factor for Coronary Artery Disease in the UK

Abstract

Homozygosity for a common NOS 3 polymorphism (894 G-->T) which encodes a Glu298-->Asp amino acid substitution in eNOS is a risk factor for angiographic CAD and recent MI in this population.