An aldose reductase inhibitor prevents glucose-induced increase in transforming growth factor-? and protein kinase C activity in cultured human mesangial cells

High glucose-induced proliferation in mesangial cells is reversed by autocrine TGF-β

Günter Wolf, Kumar Sharma, Ying Chen et al. · Kidney International · 1992 · 355 citations · Full text

Life Sciences, Biochemistry, Cell Biology +17

Hyperglycemic pseudohypoxia and diabetic complications

Joseph R. Williamson, K. Chang, M. Frangos et al. · Diabetes · 1993 · 310 citations

Medicine, Endocrinology, Internal Medicine +13

Evidence for Existence of Polyol Pathway in Cultured Rat Mesangial Cells

Ryuichi Kikkawa, Kisaburo Umemura, Masakazu Haneda et al. · Diabetes · 1987 · 113 citations · Full text

Life Sciences, Biochemistry, Cell Biology +9

Effect of Aldose Reductase Inhibitor (Tolrestat) on Urinary Albumin Excretion Rate and Glomerular Filtration Rate in IDDM Subjects With Nephropathy

Nicola Passariello, Joseph Sepe, Giuseppina Marrazzo et al. · Diabetes Care · 1993 · 73 citations

Pharmacy, Endocrinology, Pharmacotherapy +16

Intervention with the aldose reductase inhibitor, tolrestat, in renal and retinal lesions of streptozotocin-diabetic rats

Michael L. McCaleb, Mar‐Lee McKean, T. C. Hohman et al. · Diabetologia · 1991 · 56 citations · Full text

Medicine, Biochemistry, Ophthalmology +15