Selective Azetidine and Tetrahydropyridine Formation via Pd-Catalyzed Cyclizations of Allene-Substituted Amines and Amino Acids

Abstract

[reaction: see text] By choosing the right substituents either highly functionalized unusual four-membered ring amino acids or the isomeric pipecolic acid derivatives are obtained in enantiomerically pure form. Starting material is a linear allene-containing amino acid that has been resolved via biocatalysis.