Actions of the brain-penetrating H2-antagonist zolantidine on histamine dynamics and metabolism in rat brain

The determination of enzyme inhibitor constants

Martin Dixon · Biochemical Journal · 1953 · 4.1K citations · Full text

Life Sciences, Biochemistry, Biochemical Pharmacology +15

Auto-inhibition of brain histamine release mediated by a novel class (H3) of histamine receptor

Jean‐Michel Arrang, M. Garbarg, Jean‐Charles Schwartz · Nature · 1983 · 1.6K citations

Life Sciences, Neuroscience, Pharmacology +14

Highly potent and selective ligands for histamine H3-receptors

J.M. Arrang, M. Garbarg, J.-C. Lancelo et al. · Nature · 1987 · 902 citations

Medicine, Medicinal Chemistry, Pharmacology +15

Distribution of the histaminergic neuron system in the central nervous system of rats; a fluorescent immunohistochemical analysis with histidine decar☐ylase as a marker

Takehiko Watanabe, Yoshitaka Taguchi, Sadao Shiosaka et al. · Brain Research · 1984 · 817 citations

Life Sciences, Neurobiology, Neuroscience +15

Development of a new physicochemical model for brain penetration and its application to the design of centrally acting H2 receptor histamine antagonists

Rodney C. Young, Robert Cameron Mitchell, Thomas H. Brown et al. · Journal of Medicinal Chemistry · 1988 · 522 citations

Pharmacy, Medicinal Chemistry, Pharmacology +15