Novel amides and esters prodrugs of olmesartan: Synthesis, bioconversion, and pharmacokinetic evaluation

A comparison of numerical integrating algorithms by trapezoidal, Lagrange, and spline approximation

K. C. Yeh, K.C. Kwan · Journal of Pharmacokinetics and Biopharmaceutics · 1978 · 430 citations

Computing, Computational Engineering, Computer Science +12

METABOLISM OF MELATONIN BY HUMAN CYTOCHROMES P450

Xiaochao Ma, Jeffrey R. Idle, Kristopher W. Krausz et al. · Drug Metabolism and Disposition · 2004 · 321 citations

Medicine, Biochemistry, Pharmacology +13

Meldrum's acid in organic synthesis. 2. A general and versatile synthesis of .beta.-keto esters

Yuji Oikawa, Kiyoshi Sugano, Osamu Yonemitsu · The Journal of Organic Chemistry · 1978 · 301 citations

Natural Sciences, Chemistry, Bioisosterism +4

Nonpeptide Angiotensin II Receptor Antagonists:  Synthesis, Biological Activities, and Structure−Activity Relationships of Imidazole-5-carboxylic Acids Bearing Alkyl, Alkenyl, and Hydroxyalkyl Substituents at the 4-Position and Their Related Compounds

Hiroaki Yanagisawa, Yoshiya Amemiya, Takuro Kanazaki et al. · Journal of Medicinal Chemistry · 1996 · 142 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +12

Olmesartan Is an Angiotensin II Receptor Blocker with an Inhibitory Effect on Angiotensin-Converting Enzyme

Jun Agata, Nobuyuki Ura, Hideaki Yoshida et al. · Hypertension Research · 2006 · 134 citations · Full text

Pharmacy, Cardiology, Pharmacology +13