Anti-factor B autoantibody in dense deposit disease

Uncontrolled C3 activation causes membranoproliferative glomerulonephritis in mice deficient in complement factor H

Matthew C. Pickering, H. Terence Cook, Joanna Warren et al. · Nature Genetics · 2002 · 506 citations

Medicine, Immunology, Pathology +17

Mutations in Complement Factor I Predispose to Development of Atypical Hemolytic Uremic Syndrome

David Kavanagh, Elizabeth J. Kemp, Elizabeth Mayland et al. · Journal of the American Society of Nephrology · 2005 · 476 citations

Life Sciences, Genetics, Molecular Genetics +16

Gain-of-function mutations in complement factor B are associated with atypical hemolytic uremic syndrome

Elena Goicoechea de Jorge, Claire L. Harris, Jorge Esparza-Gordillo et al. · Proceedings of the National Academy of Sciences · 2006 · 445 citations · Full text

Life Sciences, Genetics, Molecular Genetics +16

Formation of the initial C3 convertase of the alternative complement pathway. Acquisition of C3b-like activities by spontaneous hydrolysis of the putative thioester in native C3.

Michael K. Pangburn, Robert D. Schreiber, Hans J. Müller‐Eberhard · The Journal of Experimental Medicine · 1981 · 443 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +10

Mutations in complement C3 predispose to development of atypical hemolytic uremic syndrome

Véronique Frémeaux‐Bacchi, Elizabeth C. Miller, M. Kathryn Liszewski et al. · Blood · 2008 · 373 citations · Full text

Life Sciences, Genetics, Hematology +14