Glyantrypine, a novel anthranilic acid-containing metabolite of Aspergillus clavatus

Abstract

The structure of a novel indole alkaloid, glyantrypine 2, a main secondary metabolite of Aspergillus clavatus has been elucidated by biosynthetic evidence, mass spectrometry and 1H and 13C NMR techniques. The compound extends the variety of metabolites biosynthesised from anthranilic acid and tryptophan without forming a benzodiazepine.