Gold(I)‐Catalyzed <i>endo</i>‐Selective Intramolecular α‐Alkenylation of β‐Yne‐Furans: Synthesis of Seven‐Membered‐Ring‐Fused Furans and DFT Calculations

Abstract

Alkenylation of furans: An efficient gold-catalyzed endo-selective intramolecular α-alkenylation of β-alkyne-substituted furans has been developed to synthesize challenging seven-membered-ring-fused furans in good to excellent yields. Preliminary DFT calculations have been carried out to understand the experimentally observed regioselectivity. DME=1,2-dimethoxyethane, Ts=p-toluenesulfonyl.