Alkyne–azide click reaction catalyzed by metallic copper under ultrasound

A Stepwise Huisgen Cycloaddition Process: Copper(I)-Catalyzed Regioselective “Ligation” of Azides and Terminal Alkynes

Vsevolod V. Rostovtsev, Luke G. Green, Valery V. Fokin et al. · Angewandte Chemie International Edition · 2002 · 11.5K citations

Natural Sciences, Chemistry, Catalysis +8

Peptidotriazoles on Solid Phase:  [1,2,3]-Triazoles by Regiospecific Copper(I)-Catalyzed 1,3-Dipolar Cycloadditions of Terminal Alkynes to Azides

Christian W. Tornøe, Caspar Christensen, Morten Meldal · The Journal of Organic Chemistry · 2002 · 8.5K citations

Pharmacy, Medicinal Chemistry, Catalysis +12

Bioorthogonal Chemistry: Fishing for Selectivity in a Sea of Functionality

Ellen M. Sletten, Carolyn R. Bertozzi · Angewandte Chemie International Edition · 2009 · 3.1K citations · Full text

Pharmacy, Biochemistry, Molecular Biology +5

A Strain-Promoted [3 + 2] Azide−Alkyne Cycloaddition for Covalent Modification of Biomolecules in Living Systems

Nicholas J. Agard, Jennifer A. Prescher, Carolyn R. Bertozzi · Journal of the American Chemical Society · 2004 · 2.9K citations

Pharmacy, Chemical Biology, Chemistry +10

Copper(I)-Catalyzed Synthesis of Azoles. DFT Study Predicts Unprecedented Reactivity and Intermediates

Fahmi Himo, Timothy Lovell, Robert Hilgraf et al. · Journal of the American Chemical Society · 2004 · 1.7K citations

Natural Sciences, Chemistry, Medicinal Chemistry +16