Photoreceptor Protection against Light Damage by AAV-Mediated Overexpression of Heme Oxygenase-1

Abstract

Overexpression of HO-1 in photoreceptors protected themselves from subsequent cellular damage caused by intense light exposure. The anti-apoptotic mechanisms of HO-1 may be related to the induction of p38, bcl-2, and c-FLIP and to the suppression of c-fos and p53.