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<i>Tert</i>-Butyl Hydroperoxide-Induced Injury In Isolated Rat Hepatocytes: A Model for Studying Anti-Hepatotoxic Crude Drugs
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1990
Year
Anti-hepatotoxic Crude DrugsLipid PeroxidationAmino-transferase LeakageRedox BiologyToxicological MechanismOxidative StressIsolated RatTert-butyl Hydroperoxide InducesToxicologyHepatotoxicityPhytochemicalHealth SciencesBiochemistryLiver PhysiologyReactive Oxygen SpecieMetabolomicsPharmacologyDrug-induced Liver InjuryHepatologyPhysiologyMetabolismMedicine
Tert-butyl hydroperoxide induces in freshly isolated rat hepatocytes malonaldehyde formation and lacticodehydrogenase and aspartate amino-transferase leakage. This model, when adapted to crude extracts, permits the demonstration of both anti-lipoperoxidant and antihepatotoxic activity of reference products like quercetin and silymarin and plant extracts like Rosmarinus officinalis and Eschscholzia californica.