Early-onset Rhabdomyolysis Associated With Daptomycin

Abstract

Daptomycin is a novel antibacterial agent that was approved in 2003 by the Food and Drug Administration for complicated skin infections. Although musculoskeletal toxicity is a known potential complication of this medicine, published case reports are rare. Prior observations of daptomycin-related rhabdomyolysis mainly involved preliminary trials that used higher dosing regimens than currently recommended, with symptoms generally occurring greater than a week after initiation of therapy. We report a case of rhabdomyolysis secondary to daptomycin that occurred early in the course of administration using current recommended dosing parameters.